Vortrag Brain & Behaviour

Public Event
08. November 2018
Hauptgebäude, Raum W0-135

Regarding fish brain anatomy, there is currently an ongoing discussion on whether specific parts of the brain should be grouped as one area or not. But what can be done if standard techniques like histology or an analysis of the areas’ functions fail to settle the argument? An unbiased observer, purely deciding on the molecular composition of the brain which parts can be grouped and which not, might help to favour one hypothesis over another. But how does such an “observer” look like? Which methods can be used the collect the necessary data? How can the data be analysed and how can the results be interpreted? During an interdisciplinary research project in the Active Sensing lab (Prof. Jacob Engelmann) those questions have been tackled. As a result, the molecular composition of zebrafish brain slices was obtained by MALDI-ToF Mass Spectrometry which, in turn, can be used to create a spatial segmentation of the slice via regularized nearest shrunken centroid clustering. But what this means in detail – apart from creating colourful images of brain slices – will be explained in course of the talk.